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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can lower panobinostat stages by ~70% and result in cure failure.pentobarbital will lessen the level or influence of carvedilol by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep an eye on